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Genetic Tech Investigations

Module Overview

Genetic technologies like DNA sequencing, flow cytometry, mass spectrometry, and live cell imaging are vital for diagnosing diseases. This module highlights the technology researchers use to explore molecular processes and understand genetic disorders. It provides a different spin on the pathway from DNA to mRNA to protein, while reinforcing molecular genetics concepts.

Prerequisite Knowledge

Students who complete the unit Exploring Genetics through Genetic Disorders should have the prerequisite knowledge for this module.

For those who have not completed the above unit, a list of prerequisite learning objectives and suggested review materials can be found here.

Learning Objectives

  • Students will recognize that genetic technologies employ biochemical processes.
  • Students will understand and apply their understandings that information transfer gone wrong could be observable at any level: DNA, mRNA, protein, protein function.
  • Students will use data from genetic technologies to draw conclusions about what may be happening to identify disorders and predict consequences.

Suggested Lesson Sequence

Class time (minutes)ActivityDescription
15-20Illuminating with TechnologyThis interactive describes how 4 different technologies illuminate our understanding of the flow of genetic information (genetic information in DNA is copied into mRNA, which provides the instructions for building proteins).
15-20Getting Off TrackThis interactive illustrates some of the many ways the flow of genetic information can go awry.
40-70From Alleles to AnswersThis paper activity tasks students with analyzing data from the featured genetic technologies to model how the flow of genetic information has gotten off track in a particular case.
6-18Visit a Lab from Three PerspectivesWhat does a medical testing lab look like and who works there? Check out these three videos of the same lab shot from different perspectives. Pick one or more to share with your students.

These materials were designed to be used flexibly; either together as a lesson, or separately to supplement other materials, in any order. Here is an example of how we used the materials together during field testing, along with discussion prompts that connect them to careers.

About this Unit

Credits

This work was supported by a Science Education Partnership Award (1R25GM142087) from the National Institute of General Medical Sciences of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.