1. CAUSE AND EFFECT
Have students fill in the Cause and Effect section of the lab notebook, as it relates to their assigned allele. Creating these statements should help them summarize the major features of their allele and disorder.
- Students should already have the information they need in their Lab Notebooks; they just need to find it and fill it in here.
Students who studied alleles of the same disorder meet and fill in the similarities and differences chart in the Symposium section of the Lab Notebook. They should be able to connect molecular-level details to observable effects at the tissue and whole-organism levels.
In comparing their alleles, students should refer to:
- Their Cause & Effect statements
- Their genetic disorder web page
- Any other relevant section in their lab notebooks
Students should find that while the overall effects of the disease-causing alleles at the whole-organism level may be similar, there are also differences. For example:
- Each allele is different at the DNA level, because they came about through different mutations. Encourage students to focus on where in their gene the mutation is, and the type of change it causes in the protein.
- Some alleles of the same gene can affect different cell and tissue types, leading to a different set of symptoms at the organism level.
- For all the genetic disorders, some alleles cause more severe symptoms than others.
- There are differences in the data graphs in each Allele Profile. It may be useful to have students compare their data graphs and relate them to the one on the genetic disorder web page.
3. FINAL PROJECT (optional)
Have each disorder group share information with the whole class. Challenge students to think about why their proteins work differently.
Here are some ideas:
- A gallery walk of the similarities and differences charts created for each disorder during the Symposium
- A PowerPoint presentation about the disorder at the protein, cellular, tissue, organ, and organism levels, including main differences between the alleles studied
- A "research poster" summarizing the disorder at the protein, cellular, tissue, organ, and organism levels, including main differences between the alleles
- Oral presentations about how their assigned allele causes the disorder